Family history of diabetes: a risk analysis
Year: 2014
Type: dissertation
Abstract: Family history of diabetes (FHD) has been recognized over the years as an important risk factor of the disease. Thus herein we evaluate the importance of FHD in the development of the three more prevalent types of diabetes, namely type 1 diabetes (T1D), Latent autoimmune diabetes of adults (LADA) and type 2 diabetes. Our research study can be divided in two different parts: study 1, a clinico-epidemiological study with a sample of 16.874 clinic files of people with diabetes (T1D, LADA and T2D); study 2, a preliminary clinic study with 23 siblings of type 2 diabetic patients. The metabolic profile of siblings was assessed with the performance of a modified OGTT with blood collections (0, 30, 90 and 120 mins). The results of study 1 indicated that the presence of a sibling with T1D or a sibling with T2D is the high risk factor among FHD to develop T1D (14-fold) or T2D (6-fold), respectively. The high risk factor to develop LADA is the presence of different types of diabetes in parents (11-fold). The study 1 also indicated that type 2 diabetes was the prevalent type of diabetes among the siblings of each type of people with diabetes evaluated. Thus, in study 2 we addressed the hypothesis that siblings of type 2 diabetics have a risk to develop diabetes and for that we evaluated their metabolic profile. The results of this study indicated a high prevalence of obesity among the siblings-T2D, mainly visceral, high levels of LDL-cholesterol, low levels of HDL-cholesterol as well as high prevalence of fatty liver disease. These features can be related with a lower decrease of hepatic insulin clearance in the first 30 minutes of the OGTT. It was concluding that presence of diabetes in siblings is the high risk factor to develop T1D and T2D, and this fact can be related with impairment in hepatic insulin clearance process.
Author: Pedro André Mendes Mataloto
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W206758918