Leptin expression and action: New experimental paradigms
Year: 1997
Type: article
Abstract: As is the case with insulin and its receptor in diabetes, mutations of leptin and its receptor are rare in human obesity (7, 8) (none have yet been described), and most obese individuals have higher levels of serum-immunoreactive leptin than do nonobese individuals, raising the specter of “leptin resistance” (9, 10). Although absolutely increased compared with lean individuals, leptin levels may be relatively lower as a function of body fat content in some obese individuals than in others, and individuals with relatively “low leptin” may be more likely to gain weight over subsequent years (11). It will be interesting to determine whether these lower levels …
Author: Jeffrey S. Flier
Institution: Beth Israel Deaconess Medical Center
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2067813652