Work

Enzyme Immunoassay versus Latex Agglutination Cryptococcal Antigen Assays in Adults with Non-HIV-Related Cryptococcosis

Year: 2014

Type: article

Abstract: We compared paired enzyme immunoassay (EIA) and latex agglutination (LA) assay results with 185 blood and 164 cerebrospinal fluid (CSF) samples from 44 and 33 non-HIV cryptococcosis patients, respectively. The LA assay cutoff of 1:256 in the blood and 1:32 in the CSF was most highly predictive of a positive EIA result. The EIA missed 18.4% detected by the LA assay in the blood samples and 7.8% detected by the LA assay in the CSF samples. We note here the improved sensitivity of the LA assay over the EIA in non-HIV patients.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.02017-14

Authors: Anil A. Panackal, John P. Dekker, Michael Proschan, Andrea Beri, Peter R. Williamson

Institutions: National Institutes of Health, Uniformed Services University of the Health Sciences, National Institute of Allergy and Infectious Diseases, National Institutes of Health Clinical Center

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, Uniformed Services University of the Health Sciences, National Institute of Allergy and Infectious Diseases