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Neurofibrillary tau pathology modulated by genetic variation of α‐synuclein

Year: 2008
Type: article
Study design: Observational Study
Abstract: We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.
DOI: 10.1002/ana.21446
Authors: Terhi Peuralinna, Minna Oinas, Tuomo Polvikoski, Anders Paetau, Raimo Sulkava, Leena Niinistö, Hannu Kalimo, Dena Hernandez, John Hardy, Andrew Singleton, Pentti J. Tienari, Liisa Myllykangas
Institutions: University of Helsinki, Helsinki University Hospital, Newcastle University, Kuopio University Hospital, National Institutes of Health, National Institute on Aging, University College London, Folkhälsans Forskningscentrum
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2068070350
FWCI: 1.917
Cites: 22
Cited by: 21
Related to: 10