Local Anaesthetics Including Benzyl Alcohol Activate the Adenylate Cyclase in Trypanosoma brucei by a Calcium‐Dependent Mechanism
Year: 1982
Type: article
Abstract: 1. The adenylate cyclase of Trypanosoma brucei is activated by local anaesthetics. 2. Activation of adenylate cyclase by the local anaesthetic, benzyl alcohol, requires Ca2+. 3. The kinetics of the presteady state reveal that the activation step occurs prior to and is separate from the catalytic step. 4. The activation step in the presence of Ca2+ can be stimulated some 200-fold and is highly co-operative with respect to benzyl alcohol concentration. 5. The mechanism by which local anaesthetics activate may be by exposing the Ca2+ -binding site of the Ca2+ receptor which is oriented towards the hydrophobic regions of the plasma membrane in the basal state.
Source: European Journal of Biochemistry
Authors: H. Paul VOORHEIS, B. Richard MARTIN
Institutions: Trinity College Dublin, University of Cambridge
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2068172668