Work

Ehlers–Danlos syndrome: A showcase of conditions that lead to understanding matrix biology

Year: 2013

Type: review

Abstract: The Ehlers-Danlos syndromes (EDS) are genetically and clinically diverse disorders in which affected individuals share a number of physical characteristics, including joint hypermobility, skin extensibility, and tissue friability. Clinical investigations opened the door to identifying the biochemical and molecular etiologies of this diverse but overlapping group of disorders. In this article, we provide an overview of how these disorders inform our understanding of matrix biology, including the role of collagens (types I, III and V), proteoglycans and other proteins.

Source: Matrix Biology

DOI: 10.1016/j.matbio.2013.07.005

Authors: Peter H. Byers, Mitzi L. Murray

Institution: University of Washington

Language: English

Topic: Connective tissue disorders research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,280