Work

A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics

Year: 2011

Type: article

Abstract: Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II facilitates recruitment of chromatin remodeling complexes as well as other factors required for productive elongation.

Source: Transcription

DOI: 10.4161/trns.2.2.14638

Authors: Marla M. Spain, Chhabi K. Govind

Institution: Oakland University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: National Institute of General Medical Sciences

Award: G4477920497