Work

Infusion of Non-HLA Matched, Off-the-Shelf Ex Vivo Expanded Cord Blood Progenitor Cells in Patients Undergoing Myeloablative Cord Blood Transplantation Is Safe and Decreases the Time to Neutrophil Recovery

Year: 2012

Type: article

Abstract: With the goal of overcoming the significant delay in ANC recovery following cord blood transplantation (CBT), we have developed a clinically feasible methodology utilizing Notch ligand for ex vivo generation of increased numbers of CD34+ cells. Having previously demonstrated a significant reduction in ANC recovery time in patients receiving these partially HLA-matched expanded cells in a myeloablative CBT, we are now evaluating whether this product could also support rapid myeloid recovery when used as a non-HLA matched, off-the-shelf product.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.003

Authors: C. Delaney, F. Milano, H. Shelly, I. Nicoud, I.D. Bernstein

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650