P3‐163: Prevalence of cognitive impairment and dementia in a cohort of oldest old in Brazil: The Pietà study
Year: 2009
Type: article
Study design: Observational Study
Abstract: Few data are available on the prevalence of cognitive impairment among the oldest-old population of developing countries. The goal of this study was to determine the prevalence of cognitive impairment no dementia (CIND) and dementia in a cohort of Brazilian oldest-old individuals and the associated sociodemographic and clinical variables. The study was conducted in the rural and urban areas of the city of Caeté, Minas Gerais state, Brazil. The city has 1,155 subjects aged 75 years or more (oldest-old) according to the 2007 Brazilian census. We aimed to evaluate at least 50% of these individuals. The selected random sample was submitted to a general personal and health questionnaire, the Mini-Mental State Examination, the Pfeffer Functional Activities Questionnaire, a brief cognitive evaluation (delayed recall task, category fluency and clock drawing), the Geriatric Depression Scale, the Mini International Neuropsychiatric Interview and to physical and neurological examination. Individuals with suspected cognitive impairment and a subset of cognitively healthy individuals were also submitted to a comprehensive neuropsychological and functional evaluation. Dementia and CIND were diagnosed according to standard criteria, accounting for the educational level, after an extensive two-phase clinical consensus discussion. 639 individuals (55.3% of the total oldest-old population) were fully evaluated, being 408 women (63.8%) and 231 men (36.2%), aged 81.1 ± 5.2 years, with mean schooling of 2.6 ± 2.8 years. Dementia was diagnosed in 176 subjects, (prevalence=27.5%), while CIND was identified in 166 (prevalence=26.0%). Among dementia patients, only 39 cases (6.1%) had a previous diagnosis of this condition. Patients with dementia were significantly older (p<0.0001) and less educated (p=0.001). Prevalence of dementia was also higher in women, although the difference was not statistically significant (p=0.06). CIND prevalence was similar in both genders. When compared with the cognitively healthy individuals (n=227), CIND subjects were significantly older (p=0.004), but had a similar schooling. A previous history of depression was more frequent among dementia (p=0.002) and CIND (p=0.007) patients. Prevalence of CIND and dementia was high in this oldest-old population, although dementia was highly under-diagnosed. Age and previous history of depression were associated with both diagnoses, while low education dementia was associated only with dementia.
Source: Alzheimer s & Dementia
Authors: Paulo Caramelli, Antonio L. Teixeira, Maira T. Barbosa, Ana Paula Santos, Marcelo Pellizzaro, Henrique C. Guimarães, Rogério G. Beato, B. Machado João Carlos, Hellen Marra, Etelvina L. Santos, Patrícia P.A. Fialho, Thais H. Machado, Viviane A. Carvalho, Anne M. Koenig, Mariana A. Almeida, Simone R. Fonseca, Cerise F.A. Coutinho, Elisa França, Natali F. Dezontini, Clarissa V. Moreira, Debora P. Maia, Mauro Q. Cunningham, Emília Sakurai
Institution: Universidade Federal de Minas Gerais
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2068869882