Work

Failure of memory T cells to induce GVHD is a result of an abortive alloresponse

Year: 2006

Type: article

Abstract: We and others previously reported that effector memory T cells (TEM) can not cause graft-versus-host disease (GVHD). In the current study, we further investigated the potential of this approach, the role of central memory T cells (TCM) in GVHD, and the underlying mechanisms. The study was mainly performed in a major histocompatibility complex mismatched model (unprimed C57BL/6 [H2b] to BALB/c [H2d]). Naive T cells (CD62L+CD45RB+CD44low), memory T cells (all other T cells except naive T cells), TCM (both CD62L+CD45RB− and CD62L+CD45RB+CD44high), and TEM (CD62L−) were obtained by cell sorting.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.214

Authors: B.J. Chen, D. DeOliveria, X. Cui, N.J. Chao

Institution: Duke Medical Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650