Work

A Practical Synthesis of Isotopically Labelled 1-(4-Isothiocyanatophenyl)-4-(t-butyl)-2,6,7-trioxabicyclo[2.2.2]octane, a Probe for the Benzodiazepine Receptor Coupled Chloride Ionophore

Year: 1991

Type: article

Abstract: An efficient synthesis of high specific activity [ 3 H]1-(4-isothiocyanato-3,5-ditritiophenyl)-4-(t-butyl)-2,6,7-trioxa-bicyclo[2.2.2]octane([ 3 H]-1), an affinity ligand for the benzodiazepine (BZ)-coupled γ-aminobutyric acid (GABA)-gated chloride channel, was achieved starting with methyl p-aminobenzoate and 3-(t-butyl)-3-oxetanemethanol.

Source: Heterocycles

DOI: 10.3987/com-91-5831

Authors: Kenner C. Rice, Brian R. de Costa, Anita Lewin, Joyce A. Schoenheimer, Phil Skolnick

Language: English

Topic: Chemical Reactions and Isotopes

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W2068937339

FWCI:

Cites:

Cited by: 2

Related to: 10