Work

Human Th17 cells in patients with cancer

Year: 2012

Type: article

Abstract: The role of interleukin-17 (IL-17)-secreting CD4(+) T (Th17) cells in cancer is under intense investigation. We have demonstrated that CCR4(+)CCR6(+) Th17 cells not only are increased in the peripheral blood of patients affected by hepatocellular carcinoma, but also suppress CD8(+) T-cell functions in vitro. These results suggest that Th17 cells may exert immunosuppressive functions in hepatocellular carcinoma.

Source: OncoImmunology

DOI: 10.4161/onci.21245

Authors: Tim F. Greten, Fei Zhao, Jaba Gamrekelashvili, Firouzeh Korangy

Institutions: National Institutes of Health, National Cancer Institute

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913