Work

The Future of Aminoglycosides: The End or Renaissance?

Year: 2010

Type: review

Abstract: Although aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front-line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV-1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.

Source: ChemBioChem

DOI: 10.1002/cbic.200900779

Authors: Jacob L. Houghton, Keith D. Green, Wenjing Chen, Sylvie Garneau‐Tsodikova

Institution: University of Michigan

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Eli Lilly and Company, University of Michigan, United States-Israel Binational Science Foundation