Work

Plasma Membrane Ca2+ATPase 2 Contributes to Short-Term Synapse Plasticity at the Parallel Fiber to Purkinje Neuron Synapse

Year: 2007

Type: article

Abstract: Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA2-/- knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.0069-07.2007

Authors: Ruth M. Empson, Molly L. Garside, Thomas Knöpfel

Institutions: Royal Holloway University of London, University of Otago, RIKEN Center for Brain Science, RIKEN

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funders: Directorate for Biological Sciences, RIKEN, RIKEN Brain Science Institute

OpenAlex ID: W2069227664