Work

Catalytic, Asymmetric Halofunctionalization of Alkenes—A Critical Perspective

Year: 2012

Type: review

Abstract: Despite the fact that halogenation of alkenes has been known for centuries, enantioselective variants of this reaction have only recently been developed. In the past three years, catalytic enantioselective versions of halofunctionalizations with the four common halogens have appeared and although important breakthroughs, they represent just the very beginnings of a nascent field. This Minireview provides a critical analysis of the challenges that accompany the development of general and highly enantioselective halofunctionalization reactions. Moreover, the focus herein, diverges from previous reviews of the field by identifying the various modes of catalysis and the different strategies implemented for asymmetric induction.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201204347

Authors: Scott E. Denmark, William E. Kuester, Matthew T. Burk

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Asymmetric Catalysis in Main Group Chemistry