Work

Guide-star-based computational adaptive optics for broadband interferometric tomography

Year: 2012

Type: article

Abstract: We present a method for the numerical correction of optical aberrations based on indirect sensing of the scattered wavefront from point-like scatterers ("guide stars") within a three-dimensional broadband interferometric tomogram. This method enables the correction of high-order monochromatic and chromatic aberrations utilizing guide stars that are revealed after numerical compensation of defocus and low-order aberrations of the optical system. Guide-star-based aberration correction in a silicone phantom with sparse sub-resolution-sized scatterers demonstrates improvement of resolution and signal-to-noise ratio over a large isotome. Results in highly scattering muscle tissue showed improved resolution of fine structure over an extended volume. Guide-star-based computational adaptive optics expands upon the use of image metrics for numerically optimizing the aberration correction in broadband interferometric tomography, and is analogous to phase-conjugation and time-reversal methods for focusing in turbid media.

Source: Applied Physics Letters

DOI: 10.1063/1.4768778

Authors: Steven G. Adie, Nathan D. Shemonski, Benedikt W. Graf, Adeel Ahmad, P. Scott Carney, Stephen A. Boppart

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Awards: G2100095715, G6854890528