Work

Molecular-Genetic Mapping of Zebrafish Mutants with Variable Phenotypic Penetrance

Year: 2011

Type: article

Abstract: Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable strategy to map zebrafish mutants with subtle phenotypes.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0026510

Authors: Roshan A. Jain, Marc A. Wolman, Lauren A. Schmidt, Harold A. Burgess, Michael Granato

Institution: University of Pennsylvania

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382