Work

Infection strategies of enteric pathogenic Escherichia coli

Year: 2012

Type: review

Abstract: Enteric Escherichia coli (E. coli) are both natural flora of humans and important pathogens causing significant morbidity and mortality worldwide. Traditionally enteric E. coli have been divided into 6 pathotypes, with further pathotypes often proposed. In this review we suggest expansion of the enteric E. coli into 8 pathotypes to include the emerging pathotypes of adherent invasive E. coli (AIEC) and Shiga-toxin producing enteroaggregative E. coli (STEAEC). The molecular mechanisms that allow enteric E. coli to colonize and cause disease in the human host are examined and for two of the pathotypes that express a type 3 secretion system (T3SS) we discuss the complex interplay between translocated effectors and manipulation of host cell signaling pathways that occurs during infection.

Source: Gut Microbes

DOI: 10.4161/gmic.19182

Authors: Abigail Clements, Joanna C. Young, Nicholas Constantinou, Gad Frankel

Institution: Imperial College London

Language: German

Topic: Escherichia coli research studies

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2069741608

FWCI: 2.876

Cites: 194

Cited by: 377

Related to: 9