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Acute Hepatic Failure in a Child Treated With Lamotrigine

Year: 1998

Type: article

Abstract: An 8-year-old boy with a known seizure disorder that was being treated with lamotrigine developed acute hepatic failure. The patient, who had been well previously, presented with jaundice, elevated liver enzymes, and a coagulopathy. After discontinuation of lamotrigine and aggressive resuscitation, the patient made an uneventful recovery. We believe that the hepatic failure in our patient was secondary to the use of lamotrigine. We recommend careful monitoring of liver function when lamotrigine is administered.

Source: Pediatric Neurology

DOI: 10.1016/s0887-8994(97)00196-3

Authors: Ronen Arnon, Darryl DeVivo, Amy R. Defelice, Philip G. Kazlow

Institutions: Columbia University Irving Medical Center, Columbia University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,520