The effect of extracorporeal shock wave lithotripsy (ESWL) on electrophysiological parameters across abdominal frog skin: Real time observations
Year: 1990
Type: conference-abstract
Abstract: The side effects of ESWL, such as increased sodium excretion and proteinuria, may be explained by structural and functional changes that lead to an increase in permeability across the renal tubule. This preliminary study was undertaken to examine the feasibilty of such an explanation. Frog skin was used in this investigation, since sodium transport across it is similar to that of the distal convoluted tubule in the kidney. Exposure of the skin to a single shock at 20-kV electrode voltage caused a significant but reversible decrease in transepithelial membrane potential, a decrease in ionic current (primarily sodium), and an increase in total ionic permeability. It is of interest to note here that these results are similar to those reported by Dinno et al. [Ultrasound Med. Biol. 15, 461–470 (1989)] on the effect of therapeutic ultrasound (1 MHz, 60–480 mW/cm2) on frog skin. Those similarities suggest a common mechanism. On the basis of this observation and other unpublished results, acoustic cavitation, and consequent free radical formation, seem to be an important factor contributing to the observed side effects. [Work supported by NIH under Grant No. 5-RO1-CA-39374-05. We gratefully acknowledge Dornier for making available their experimental lithotripter.]
DOI: 10.1121/1.2028729
Institution: University of Mississippi
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2069786469