Work

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

Year: 1993

Type: article

Abstract: The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.37.1.128

Authors: A A Neyfakh, C M Borsch, G W Kaatz

Institution: University of Illinois Chicago

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2069814511

FWCI: 7.657

Cites: 6

Cited by: 365

Related to: 10