Work

Microbial stimulation as an aetiologic factor in atopic disease

Year: 1999

Type: article

Abstract: Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.

Source: Allergy

DOI: 10.1111/j.1398-9995.1999.tb04382.x

Authors: P. G. Holt, C. Macaubas, S. L. Prescott, P. D. Sly

Institution: The Kids Research Institute Australia

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2069834634

FWCI: 4.008

Cites: 36

Cited by: 61

Related to: 10