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Human baroreflex rhythms persist during handgrip and muscle ischaemia

Year: 2013
Type: article
Abstract: AIM: To determine whether physiological, rhythmic fluctuations of vagal baroreflex gain persist during exercise, post-exercise ischaemia and recovery. METHODS: We studied responses of six supine healthy men and one woman to a stereotyped protocol comprising rest, handgrip exercise at 40% maximum capacity to exhaustion, post-exercise forearm ischaemia and recovery. We measured electrocardiographic R-R intervals, photoplethysmographic finger arterial pressures and peroneal nerve muscle sympathetic activity. We derived vagal baroreflex gains from a sliding (25-s window moved by 2-s steps) systolic pressure-R-R interval transfer function at 0.04-0.15 Hz. RESULTS: Vagal baroreflex gain oscillated at low, nearly constant frequencies throughout the protocol (at approx. 0.06 Hz - a period of about 18 s); however, during exercise, most oscillations were at low-gain levels, and during ischaemia and recovery, most oscillations were at high-gain levels. CONCLUSIONS: Vagal baroreflex rhythms are not abolished by exercise, and they are not overwhelmed after exercise during ischaemia and recovery.
DOI: 10.1111/apha.12143
Authors: D. L. Eckberg, W. H. Cooke, A. Diedrich, B. D. Levine, J. A. Pawelczyk, J. C. Buckey, A. C. Ertl, I. Biaggioni, J. F. Cox, D. Robertson, F. J. Baisch, C. G. Blomqvist, T. A. Kuusela, K. U. O. Tahvanainen
Institutions: Virginia Commonwealth University, Hunter Holmes McGuire VA Medical Center, Virginia Commonwealth University Medical Center, The University of Texas at San Antonio, Vanderbilt University, The University of Texas Southwestern Medical Center, Pennsylvania State University, Dartmouth–Hitchcock Medical Center, Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR), University of Turku, South Karelia Central Hospital
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2069853222
FWCI: 0.227
Cites: 48
Cited by: 6
Related to: 10