Work

Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

Year: 1992

Type: article

Abstract: The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.8.3414

Authors: Y Kasai, J R Nambu, P M Lieberman, S T Crews

Institution: University of California, Los Angeles

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: MOLECULAR BIOLOGY OF NEUROGENESIS, G1760095324, G3750127205, Tumor Cell Biology Training Program