The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity
Year: 2012
Type: article
Abstract: Type 2 diabetes (T2D) and obesity are complex disorders that constitute major public health problems. The evidence for familial aggregation of both T2D and obesity is substantial. To date, more than 150 genetic loci are associated with the development of monogenic, syndromic, or multifactorial forms of T2D or obesity. However, the proportion of overall trait variance explained by these associated loci is modest (~5-10% for T2D, ~2% for body mass index (BMI)). Some of the familial aggregation not attributable to known genetic variation, as well as many of the effects of environmental exposures, may reflect epigenetic processes. In this review, we discuss the evidence concerning the genetic contribution to individual risk of T2D and obesity, and explore the potential role of epigenetic mechanisms. We also explain how genetics, epigenetics, and environment are likely to interact to define the individual risk of disease.
Authors: A W Drong, C M Lindgren, M I McCarthy
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funder: Wellcome Trust
Awards: Genetics and genomics of central obesity ., Genetics and genomics of central obesity., Genomic Medicine and Statistics, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., Comprehensive assessment of the role of methylation in Obesity and Type 2 Diabetes, using a combined genetics and cell biology approach
OpenAlex ID: W2069895399