Influence of gender on receipt of guideline-based antiretroviral therapy in the era of HAART
Year: 2011
Type: article
Abstract: United States HIV guidelines delineate preferred antiretroviral treatment (ART) and discourage use of sub-potent, toxic, or adversely interacting combinations. It is unclear how often patients receive guideline concordant ART and what factors are correlated with receiving guideline-inconsistent ART. The objective of this study was to assess ART reported by participants of the Women's Interagency HIV Study (WIHS) and the Multicenter AIDS Cohort Study (MACS) to determine whether gender is associated with receipt of guideline-inconsistent ART. ART reported by WIHS and MACS participants from 1 January 2001, to 31 December 2007, was assessed for concordance with HIV guidelines. Logistic regression with generalized estimating equations estimated the crude and adjusted odds ratios and 95% confidence intervals associated with guideline-inconsistent regimens. Of 2937 participants, 463 subjects (WIHS n = 263; MACS n = 200) reported guideline-inconsistent ART during the study period. Age > 50 years (aOR = 2.22, 95% CI 1.14, 4.33) and HIV-1 RNA (aOR = 1.17, 95% CI 1.08, 1.25) but not participant gender (aOR = 1.21, 95% CI 0.88, 1.65) were associated with guideline-inconsistent ART. The prevalence of guideline-inconsistent ART peaked in 2004; however, there was not a statistically significant increase or decrease over time. Guideline-inconsistent ART was not related to gender, but was often used by older patients and patients with higher viral loads. Monitoring ART quality based on concordance with expert guidelines could improve treatment outcomes in a substantial number of patients.
Source: AIDS Care
Authors: Jennifer M. Cocohoba, Keri N. Althoff, Rebecca Godfrey, Frank J. Palella, Ruth M. Greenblatt
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1052830664, G1089263533, G1252706584, G1383752764, G1474614938, G1648982045, Clinical and Translational Science Institute, G2017072594, G2072110039, G2088232294, G2574405597, G2674972404, G2821333946, The Connie Wofsy Women's HIV Study, G344188330, G346824799, G3481933404, Brooklyn Women's Interagency HIV Study (WIHS) V, G359857122, Natural History of AIDS in Homosexual Men, WIHS Data Management and Analysis Center (WDMAC), G483408255, G499585988, Chicago WIHS Consortium V (CWC), G51363488, Center/Coordination, Analysis and Management/MACS, Washington Women's Interagency HIV/AIDS Study, G592158972, G6120741853, Beyond Pill-Counting: Effect of Pharmacist Counseling on Antiretroviral Adherence, UCSF-Kaiser Department of Research Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Program, G669420692, Multicenter AIDS Cohort Study, G714446084, G773494495, G826976987, G925273713, G97119092, G986692823
OpenAlex ID: W2070060347