Work

Dendrimer-like PEO Glycopolymers Exhibit Anti-Inflammatory Properties

Year: 2005

Type: article

Abstract: A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja0511974

Authors: Shyam M. Rele, Wanxing Cui, Lianchun Wang, Sijian Hou, Ginger Barr-Zarse, Daniel Tatton, Yves Gnanou, Jeffrey D. Esko, Elliot L. Chaikof

Institutions: Georgia Institute of Technology, Emory University, Laboratoire de Chimie des Polymères Organiques

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G2994681429, G3616370761, G4157207099, Syndecan-1 in Aortic Aneurysm Formation, G8355891975, Molecularly Engineered Blockade of Islet Induced Inflammatory Responses

OpenAlex ID: W2070128508

FWCI: 10.23

Cites: 24

Cited by: 132

Related to: 10