Year: 1997
Type: review
Abstract: Morphological data suggest that Golgi cisternae form at the cis-face of the stack and then progressively mature into trans-cisternae. However, other studies indicate that COPI vesicles transport material between Golgi cisternae. These two observations can be reconciled by assuming that cisternae carry secretory cargo through the stack in the anterograde direction, while COPI vesicles transport Golgi enzymes in the retrograde direction. This model provides a mechanism for cisternal maturation. If Golgi enzymes compete with one another for packaging into COPI vesicles, we can account for the asymmetric distribution of enzymes across the stack.
Source: FEBS Letters
Authors: B S Glick, T Elston, G Oster
Institutions: University of Chicago, University of California, Berkeley
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
Funder: National Science Foundation
OpenAlex ID: W2070131512