Work

Protein Ionizable Groups: pK Values and Their Contribution to Protein Stability and Solubility

Year: 2009

Type: review

Abstract: The structure, stability, solubility, and function of proteins depend on their net charge and on the ionization state of the individual residues. Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment. We review what has been learned about pK values of ionizable groups in proteins from experimental studies and discuss the important contributions they make to protein stability and solubility.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r800080200

Authors: C. Nick Pace, Gerald R. Grimsley, J. Martin Scholtz

Institutions: Texas A&M Health Science Center, Texas A&M University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W2070144513

FWCI: 1.573

Cites: 48

Cited by: 475

Related to: 10