Work

Regulation of potassium channels by protein kinases

Year: 1996

Type: review

Abstract: Studies of the role of protein phosphorylation in the modulation of neuronal excitability are beginning to identify specific sites on ion channels that are substrates for serine/threonine kinases and that contribute to short-term and long-term regulation of current amplitude and kinetics. In addition, it is becoming apparent that phosphorylation of tyrosine residues may produce acute changes in the characteristics of ion channels. These recent findings are best illustrated by examining the Shaker superfamily of potassium channels.

Source: Current Opinion in Neurobiology

DOI: 10.1016/s0959-4388(96)80114-0

Authors: Elizabeth A Jonas, Leonard K Kaczmarek

Institution: Yale University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,320