Work

Controlled Deamidation of Peptides and Proteins: An Experimental Hazard and a Possible Biological Timer

Year: 1970

Type: article

Abstract: Experiments on model peptides show that the rate of deamidation of asparaginyl residues depends strongly on the nature of neighboring residues. The natural distribution of glutaminyl and asparaginyl residues is ordered with respect to the biological lifetime of the peptides and the functional groups of the residues neighboring to glutaminyl and asparaginyl residues. The rates of deamidation of such amide peptides under physiological conditions could serve as useful timers of development and aging.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.66.3.753

Authors: Arthur B. Robinson, James H. McKerrow, Paul Cary

Institution: University of California San Diego

Language: English

Topic: Protein purification and stability

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2070214907

FWCI: 3.872

Cites: 16

Cited by: 267

Related to: 10