Year: 1999
Type: article
Abstract: A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.
Source: Molecular Biology and Evolution
Authors: E. C. Holmes, M. Worobey, A. Rambaut
Institution: University of Oxford
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Wellcome Trust, Royal Society
OpenAlex ID: W2070324371