Work

Absence of a Specific Ganglioside Galactosyltransferase in Mouse Cells Transformed by Murine Sarcoma Virus

Year: 1974

Type: article

Abstract: The ganglioside composition of a nonproducer subclone (derived from BALB/c 3T3 mouseembryo cells) transformed by Kirsten murine sarcoma virus was drastically altered compared to the nontransformed parental clone. The transformed clone was unable to synthesize the mono- and disialogangliosides, G(M1) and G(D1a), due to the complete absence of a specific galactosyltransferase. The lack of this enzyme activity was established by sensitive radiochemical and enzymological techniques in vivo and in vitro.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.71.2.298

Authors: Peter H. Fishman, Roscoe O. Brady, Roy M. Bradley, Stuart A. Aaronson, George J. Todaro

Institutions: National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Cancer Institute

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2070358677

FWCI: 5.513

Cites: 24

Cited by: 69

Related to: 10