Work

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

Year: 2003

Type: article

Abstract: The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

Source: Annals of Neurology

DOI: 10.1002/ana.10639

Authors: Elaine K. Perry, Linda Kilford, Andrew J. Lees, David J. Burn, Robert H. Perry

Institutions: Newcastle upon Tyne Hospital, UCL Queen Square Institute of Neurology, University College London, The Royal Free Hospital

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2070495958