Work

Vitamin D and Non-Hodgkin Lymphoma Risk in Adults: A Review

Year: 2009

Type: review

Abstract: Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.

Source: Cancer Investigation

DOI: 10.3109/07357900902849632

Authors: Jennifer L. Kelly, Jonathan W. Friedberg, Laura M. Calvi, Edwin van Wijngaarden, Susan G. Fisher

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green