Get started
Work

376. Hepatic Tropism of Adenoviral Type 5 Vectors Can Be Mediated by Multiple Coagulation Factors

Year: 2006
Type: article
Abstract: A recent study demonstrated that Factor IX (FIX) directly binds the adenoviral (Ad) fibre knob domain |[ldquo]|bridging|[rdquo]| viral uptake into hepatocytes via heparan sulphate proteoglycans (HSPG) and/or low-density lipoprotein receptor related protein (LRP)1. In vivo, this phenomenon compensates for introduced capsid mutations abrogating CAR binding, accounting for the identical liver transduction levels of Ad5 vectors independent of CAR-binding status.
DOI: 10.1016/j.ymthe.2006.08.436
Authors: Alan L. Parker, Campbell G. Nicol, Simon N. Waddington, Suzanne M. Buckley, Dmitry M. Shayakhmetov, Shaoheng H. Ni, Andre Lieber, John H. McVey, Laura Denby, Stuart A. Nicklin, Andrew H. Baker
Language: English
Subfield: Genetics
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W2070599247
FWCI:
Cites: 1
Cited by:
Related to: 10