Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index
Year: 2015
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The Healthy Aging Index (HAI) is a tool for measuring the extent of health and disease across multiple systems. METHODS: We conducted a genome-wide association study and a genome-wide linkage analysis to map quantitative trait loci associated with the HAI and a modified HAI weighted for mortality risk in 3,140 individuals selected for familial longevity from the Long Life Family Study. The genome-wide association study used the Long Life Family Study as the discovery cohort and individuals from the Cardiovascular Health Study and the Framingham Heart Study as replication cohorts. RESULTS: There were no genome-wide significant findings from the genome-wide association study; however, several single-nucleotide polymorphisms near ZNF704 on chromosome 8q21.13 were suggestively associated with the HAI in the Long Life Family Study (p < 10(-) (6)) and nominally replicated in the Cardiovascular Health Study and Framingham Heart Study. Linkage results revealed significant evidence (log-odds score = 3.36) for a quantitative trait locus for mortality-optimized HAI in women on chromosome 9p24-p23. However, results of fine-mapping studies did not implicate any specific candidate genes within this region of interest. CONCLUSIONS: ZNF704 may be a potential candidate gene for studies of the genetic underpinnings of longevity.
Authors: Ryan L. Minster, Jason L. Sanders, Jatinder Singh, Candace M. Kammerer, M. Michael Barmada, Amy M. Matteini, Qunyuan Zhang, Mary K. Wojczynski, E. Warwick Daw, Jennifer A. Brody, Alice M. Arnold, Kathryn L. Lunetta, Joanne M. Murabito, Kaare Christensen, Thomas T. Perls, Michael A. Province, Anne B. Newman
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1023702118, G1078500014, G1220223050, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1332411685, G1462415530, CORONARY HEART DISEASE AND STROKE, G201653045, G2193588257, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, Long Life Family Study: Boston Field Center, G2391884931, G250621538, G2555954497, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G2777672791, G2800149121, G297113894, G3045517347, WGA Study to Identify Genetic Variants Associated with CV Events in CHS, G3220743633, UCLA Clinical and Translational Science Institute, G3342643523, G337426736, G34347772, G36937976, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center, G423252844, G441669668, G5164707915, G5479317095, G573134505, G581887176, CHARGE consortium: omics discovery for CVD and aging phenotypes, CHS Events Follow-up Study, G6226795708, The Framingham Heart Study, Long Life Family Study: University of Pittsburgh Field Center, Long Life Family Study: Data Management and Coordinating Center, CHS-Transition Phase, SNP HEALTH ASSOCIATION RESOURCE (SHARE), G7176672723, G777822606, CHS Events Follow-up Study, Pittsburgh Older Americans Independence Center, Diabetes Research Center (DRC), Center for Population Health and Aging, G905887895
OpenAlex ID: W2070762008