Work

BODIPY dyes in photodynamic therapy

Year: 2012

Type: review

Abstract: BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

Source: Chemical Society Reviews

DOI: 10.1039/c2cs35216h

Authors: Anyanee Kamkaew, Siang Hui Lim, Hong Boon Lee, Lik Voon Kiew, Lip Yong Chung, Kevin Burgess

Institutions: Texas A&M University, University of Malaya, Cancer Research Malaysia, Subang Jaya Medical Centre

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences