Work

Joint Coupled-Feature Representation and Coupled Boosting for AD Diagnosis

Year: 2014

Type: conference-paper

Abstract: Recently, there has been a great interest in computer-aided Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) diagnosis. Previous learning based methods defined the diagnosis process as a classification task and directly used the low-level features extracted from neuroimaging data without considering relations among them. However, from a neuroscience point of view, it's well known that a human brain is a complex system that multiple brain regions are anatomically connected and functionally interact with each other. Therefore, it is natural to hypothesize that the low-level features extracted from neuroimaging data are related to each other in some ways. To this end, in this paper, we first devise a coupled feature representation by utilizing intra-coupled and inter-coupled interaction relationship. Regarding multi-modal data fusion, we propose a novel coupled boosting algorithm that analyzes the pairwise coupled-diversity correlation between modalities. Specifically, we formulate a new weight updating function, which considers both incorrectly and inconsistently classified samples. In our experiments on the ADNI dataset, the proposed method presented the best performance with accuracies of 94.7% and 80.1% for AD vs. Normal Control (NC) and MCI vs. NC classifications, respectively, outperforming the competing methods and the state-of-the-art methods.

Source: IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings

DOI: 10.1109/cvpr.2014.354

Authors: Yinghuan Shi, Heung-Il Suk, Yang Gao, Dinggang Shen

Institutions: Nanjing University, University of North Carolina at Chapel Hill

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green