Work

Optical Coherence Tomography of the Cochlea in the Porcine Model

Year: 2008

Type: article

Abstract: OBJECTIVES/HYPOTHESIS: To demonstrate the feasibility of optical coherence tomography in microstructural imaging of the porcine cochlea. STUDY DESIGN: Ex vivo, porcine model. METHODS: Optical coherence tomographic images of the porcine cochlea were obtained by thinning the bone from the basal turn of the cochlea leaving the endosteum intact. The images were compared with the corresponding histological sections. RESULTS: In the areas of thinned bone, images were obtained of the stria vascularis, Reissner's membrane, basilar membrane, tectorial membrane, scala media, scala tympani, and scala vestibuli. The bone was too thick for adequate light penetration in the areas where it was not thinned. Good histological correlation was obtained. CONCLUSIONS: Cochlear and vestibular microanatomic structures of the pig cochlea were clearly identified with histological confirmation, suggesting the potential application of this noninvasive imaging modality for in vivo imaging of the human cochlea.

Source: The Laryngoscope

DOI: 10.1097/mlg.0b013e318173dd6c

Authors: Ali Sepehr, Hamid R. Djalilian, Janice E. Chang, Zhongping Chen, Brian J. F. Wong

Institutions: University of California, Irvine, Beckman Laser Institute and Medical Clinic

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources