Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

Year: 2000

Type: article

Abstract: A genome scan of approximately 12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

Source: The American Journal of Human Genetics

DOI: 10.1086/302697

Institutions: Lawrence Berkeley National Laboratory, Stanford University, Mayo Clinic, Cold Spring Harbor Laboratory, Whitehead Institute for Biomedical Research, Johns Hopkins University, Johns Hopkins Medicine, University of Maryland, Baltimore, Tufts University

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,150

Funders: Dana Foundation, Johns Hopkins University

OpenAlex ID: W2070954442