Work

IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation

Year: 2002

Type: article

Abstract: Naive CD4(+) T cell populations rapidly produce small amounts of IL-4 in response to T cell receptor-mediated stimulation and may undergo Th2 differentiation without exogenous IL-4. Whether this is due to autocrine IL-4-stimulation or the production of IL-4 by an infrequent naive cell has not been determined. Here we show that single CD4(+) T cells from RAG2-/- T cells receptor transgenic mice primed with their cognate antigen give rise to IL-4-producing cells at a similar frequency whether primed with or without added IL-4, but not if anti-IL-4 is added to the culture. Thus, each founder cell or one or more of its early daughters can produce sufficient IL-4 to drive Th2 differentiation. This indicates that autocrine IL-4 production by naive CD4 T cells can drive the appearance of Th2 cells.

Source: European Journal of Immunology

DOI: 10.1002/1521-4141(200205)32:5<1428::aid-immu1428>3.0.co;2-0

Authors: Nancy Noben-Trauth, Jane Hu-Li, William E. Paul

Institutions: George Washington University, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2070990855

FWCI: 1.97

Cites: 28

Cited by: 91

Related to: 10