Work

Classics in Chemical Neuroscience: Diazepam (Valium)

Year: 2014

Type: review

Abstract: Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

Source: ACS Chemical Neuroscience

DOI: 10.1021/cn5000056

Authors: Nicholas E. Calcaterra, James C. Barrow

Institutions: Johns Hopkins University, Lieber Institute for Brain Development

Language: English

Topic: Historical Medical Research and Treatments

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2071227523

FWCI: 1.405

Cites: 90

Cited by: 284

Related to: 10