Work

Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.

Year: 2014

Type: article

Abstract: Chemokines secreted by astrocytes play multiple roles in the pathology of Alzheimer's disease, a chronic inflammation disorder of central nervous system. The level of chemokines in serum, cerebrospinal fluid and brain tissue and their receptors both significantly changed in patients with Alzheimer's disease. In this review, we briefly summarized the involvement of astrocytes and chemokines in Alzheimer's disease, and the role of chemokine/chemokine receptors in the occurrence and development of Alzheimer's disease. Clarification of the involvement of chemokines and their receptors, such as MCP-1/CCR2, fractalkine/CX3CR1, SDF-1α/CXCR4, MIP-1α/CCR5, IP-10/CXCR3, IL-8/CXCR1, CXCR2, and RANTES/CCR1, CCR3, CCR5, will provide a new strategy and more specific targets for the treatment of Alzheimer's disease.

Source: Europe PMC (PubMed Central)

Authors: Chang Liu, Guohong Cui, Meiping Zhu, Xiangping Kang, Haidong Guo

Institutions: Shanghai University of Traditional Chinese Medicine, Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Shuguang Hospital

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W207124143

FWCI: 5.24

Cites: 122

Cited by: 177

Related to: 10