Work

Educational paper

Year: 2011

Type: article

Abstract: Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes. It is a paediatric emergency, which is life-threatening when recognized too late. The clinical presentation varies from the classical form of SCID through atypical SCID to Omenn syndrome. In addition, there is a considerable immunological variation, which can hamper the diagnosis. In this educational review, we describe the immunopathological background, clinical presentations and diagnostic process of SCID, as well as the therapeutic possibilities.

Source: European Journal of Pediatrics

DOI: 10.1007/s00431-011-1452-3

Authors: Mirjam van der Burg, Andy R. Gennery

Institutions: Erasmus MC, Royal Victoria Infirmary, Great North Children's Hospital, Newcastle University

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,990