Work

Central role for differential gene expression in mammalian hibernation.

Year: 1992

Type: article

Abstract: Mammalian hibernators experience dramatic reductions in body temperature, metabolic rate, respiratory rate, and heart rate during hibernation. These changes are precisely controlled and reversible with only internally driven mechanisms, suggesting specific biochemical regulation. We present a model that integrates our observations of differential liver gene expression during preparation for, and maintenance of, the hibernating state, with the known phylogenetic interspersion of hibernating species in several major mammalian lineages. This model predicts a major role for the differential expression of existing mammalian genes in the biochemical regulation of hibernation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.89.15.7119

Authors: H K Srere, L C Wang, S L Martin

Institutions: University of Colorado Health, University of Colorado Denver, University of Alberta

Language: English

Topic: Physiological and biochemical adaptations

Subfield: Ecology

Field: Environmental Science

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of Diabetes and Digestive and Kidney Diseases, Army Research Office

Awards: G3726876281, HEPATOBILIARY CENTER