Work

Continuous Synthesis and Purification by Direct Coupling of a Flow Reactor with Simulated Moving‐Bed Chromatography

Year: 2012

Type: article

Abstract: Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201202795

Authors: Alexander G. O'Brien, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel‐Morgenstern, Peter H. Seeberger

Institutions: Max Planck Society, Max Planck Institute of Colloids and Interfaces, Max Planck Institute for Dynamics of Complex Technical Systems, Otto-von-Guericke-Universität Magdeburg, Freie Universität Berlin

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2071448001

FWCI: 6.573

Cites: 48

Cited by: 95

Related to: 10