Work

Efficacy of a Single Oral Dose of Oxfendazole against Fasciola hepatica in Naturally Infected Sheep

Year: 2012

Type: article

Abstract: The efficacy of a single oral dose of 30 mg/kg of oxfendazole against Fasciola hepatica was evaluated in a controlled study in naturally infected sheep. Sheep were diagnosed by stool microscopy after sedimentation, and positive animals were randomized to oxfendazole (N = 20) or no treatment (N = 20). A new stool exam was performed 10 days after treatment. All stool microscopies were performed masked to the treatment group. No side effects were noticed. All sheep in the control group remained infected with similar counts of eggs per gram of stools. None of the animals in the treatment group showed Fasciola eggs in stools after 10 days of treatment. A single dose of oxfendazole is highly effective against F. hepatica, providing a new drug alternative for the control of fascioliasis or integrated zoonosis control.

Source: American Journal of Tropical Medicine and Hygiene

DOI: 10.4269/ajtmh.2012.11-0476

Authors: Luis A. Gomez-Puerta, Cesar Gavidia, Maria T. Lopez-Urbina, Hector H. Garcia, Armando E. Gonzalez, _ _

Institutions: National University of San Marcos, Universidad Peruana Cayetano Heredia

Language: English

Topic: Helminth infection and control

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health, Fogarty International Center