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Solvent‐Free Synthesis of Peptides

Year: 2009

Type: article

Abstract: A crush on sweetness! The coupling of a urethane-protected N-carboxyanhydride of an amino acid with another amino acid derivative under ball-milling conditions gives a protected dipeptide in very high yield (see scheme; PG: protecting group). The reaction takes place in the solid state. The synthesis was applied to the preparation of a tripeptide and the sweetener aspartame, without any organic solvent or purification.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200903510

Authors: Valérie Declerck, Pierrick Nun, Jean Martinez, Frédéric Lamaty

Institutions: Université Paris-Sud, Centre National de la Recherche Scientifique, Institut des Biomolécules Max Mousseron, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Montpellier 2

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2071905449

FWCI: 3.624

Cites: 32

Cited by: 212

Related to: 10