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Prostate Involvement During Sexually Transmitted Infections as Measured by Prostate Specific Antigen Concentration

Year: 2009

Type: conference-abstract

Abstract: Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male U.S. military members.Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.Results: Chlamydia and gonorrhea, but not NCNGU, cases were more likely to have a large rise (≥40%) in PSA than controls (33.6%, 19.1%, and 8.2% versus 8.8%, p<0.0001, 0.021, and 0.92, respectively).Conclusion: Chlamydia and gonorrhea may infect the prostate of some infected men.

Source: The Journal of Urology

DOI: 10.1016/s0022-5347(09)60189-0

Authors: Siobhan Sutcliffe, Remington L Nevin, Ratna M Pakpahan, Debra J Bruzek, Stephen R Cole, Angelo M De Marzo, Charlotte A Gaydos, William B Isaacs, William G Nelson, Lori J Sokoll, Jonathan M Zenilman, Steven B Cersovsky, Elizabeth A Platz

Institutions: Washington University in St. Louis, Alvin J. Siteman Cancer Center, University of North Carolina at Chapel Hill, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Johns Hopkins Hospital, Defense Center for Public Health - Aberdeen

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Patrick C. Walsh Prostate Cancer Research Fund

OpenAlex ID: W2072143451

Cites: 11

Cited by: 1

Related to: 10